Discrepancies were resolved by consensus. Regional (neck) nodal recurrence, overall survival (OS), and disease-specific survival (DSS) were tested.ĭata Extraction and Synthesis Four researchers independently extracted information on population characteristics, outcomes of interest, and study design. All patients included had a histopathologic diagnosis of SCC and at least 6 months of follow-up.
#Early stage cancer lymph nodes in neck series#
Study Selection Controlled clinical trials, prospective and retrospective cohorts, case-control studies, and case series that compared END with observation in patients with early-stage T1-T2 OTSCC who had no clinical or radiologic evidence of lymph node metastasis to the neck were eligible for inclusion in this meta-analysis. Search terms used were squamous cell carcinoma, oral tongue, mobile tongue, T1, T2, early stage, elective neck dissection, no neck treatment, observation, wait and watch, node- negative neck, and N0 neck.
Objective To systematically review the literature and carry out a meta-analysis of studies that compared elective neck dissection (END) with observation in patients with early-stage T1-T2 OTSCC and cN0 neck.ĭata Sources The MEDLINE, Scopus, Google scholar, and Cochrane databases were systematically searched for articles published between January 1, 1970, and June 1, 2015. Importance The elective management of no clinical or radiologic evidence of lymph node metastasis in the neck (cN0) in early stage T1-T2 oral tongue squamous cell carcinoma (OTSCC) has been the subject of much debate during the past 3 decades and continues to be controversial. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.It is necessary to consider more effective postsurgical therapy for high- risk earlystage cervical cancer. Survival of surgical cases was not improved by the introduction of the guidelines. There was no significance in the postsurgical therapy between CT and CCRT/RT (p=0.078).
For pN1 cases, the estimated subdistribution HR by the competing risk model for the influence of the guideline was 1.094 (p=0.634). Following the introduction of the first guideline in 2007, for patients with lymph node metastasis, the use of chemotherapy (CT) as a postsurgical therapy increased, whereas that of concurrent chemoradiotherapy (CCRT)/ radiotherapy (RT) decreased (p<0.010). surgery cases, the estimated subdistribution hazard ratio (HR) by the competing risk model for the influence of the guideline adjusted for age, year of registration, pT classification, pN classification, histological type, and treatment methods was 1.024 (p=0.864). Data of these patients were retrospectively reviewed, and clinicopathological trends were assessed.The influence of the introduction of the guideline on survival was determined by using a competing risk model. analysis included 9,756 patients who were diagnosed based on the pathological Tumor-Node- Metastasis (pTNM) classification (i.e., pT1b1, pT1b2, pT2b and pN0, pN1, pNX) and received surgery as a primary treatment between 20. The aim of this research was to evaluate the influence of the introduction of the first guideline on clinical trends and outcomes of patients with earlystage cervical cancer who underwent surgery. Japan Society of Gynecologic Oncology published the first guidelines for the treatment of cervical cancer in 2007.
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